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Fully sequenced samples of complimentary DNA synthesized from single-stranded, mammalian RNA. Various gene inserts sourced from humans, mice, monkeys, and other species are available. Ideal for use in gene cloning, as gene probes, and in cDNA library creation.
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This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
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Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome.
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A DNA sequence encoding the extracellular domain (Met 1-Gln 167) of human PD1 (NP_005009.2) was expressed with a C-terminal polyhistidine tag. The protein is site-specifically conjugated with PE (Excitation = 495-566 nm, Emission Max.= 575 nm).
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Nectin-2 also known as CD112 (Cluster of Differentiation 226) and PVRL2 (Poliovirus receptor-related 2) is a human plasma membrane glycoprotein This protein is a modulator of T-cell signaling and can be either a costimulator of T-cell function or a coinhibitor depending on the receptor it binds to Upon binding to CD226 it stimulates T-cell proliferation and cytokine production including that of IL-2 IL-5 IL-10 IL-13 and IFN It can also inhibit T-cell proliferation upon interaction with PVRIG Nectin-2 also acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1 herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV)
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Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF- signaling pathway which is involved in the regulation of cell proliferation migration and apoptosis Loss of ACVR2A has an important role in cancer progression and distant metastasis and may serve as a prognostic marker in patients with colon cancer
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NKp30 along with NKp44 and NKp46 constitute a group of receptors termed Natural Cytotoxicity Receptors These receptors play a major role in triggering NK-mediated killing of most tumor cells lines NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands It controls for instance NK cells cytotoxicity against tumor cells
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Human Heart full length tissue cDNA is made of RNA extracted from freshly harvested tissues of single healthy normal adult donor using classical guanidine isothiocyanate phenol: chloroform extraction method. RNA is treated with RNase-free DNase-1 to remove residual DNA. The cDNA is primed with Random Hexamer primer.
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Zyagen Full-length first strand tissue cDNA is synthesized from high quality tissue RNA which is subjected to rigorous quality control procedures to ensure the highest quality. The cDNA is primed with oligo dT primers using reverse transcriptase enable full length cDNA synthesis. Tissue cDNA is ideal for gene discovery and expression analysis applications, characterization of alternative splicing of mRNA, verification of genetic mutation, gene cloning and target sequencing. As quality control test, each cDNA sample is tested by PCR amplification using specific house-keeping gene primers. Each product is shipped in 1.5 ml-tube in reverse transcriptase buffer and is enough for 30 PCR reactions.
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